Adaptive wavelet frame methods with B-spline bases Dana Cerna It is known that a function f that is smooth, except at some isolated singularities, typically has a sparse representation in a wavelet basis, i.e. only a small number of numerically significant wavelet coefficients carry most of the information on f. This compression property of wavelets led to design of adaptive wavelet methods for solving operator equations. The effectiveness of these methods is strongly influenced by the choice of a wavelet basis. In our contribution, we propose a construction of B-spline wavelet basis on the interval and its adaptation to complementary boundary conditions. The resulting bases are well-conditioned and corresponding stiffness matrices have small condition numbers. Furthermore, we show that this construction combined with frame approach to adaptation to a fairly general bounded domain leads to effective adaptive wavelet frame methods.